Effects of SymlinSeveral studies have looked at the effects of Symlin for type 2 diabetes, particularly with regards to hemoglobin A1c, weight, and insulin dose.
Hemoglobin A1c (HbA1c) is a test used to measure long-term blood sugar control. For people without diabetes, HbA1c results are usually less than 6 percent, while people with diabetes usually have higher results. In one study of people with type 2 diabetes, people taking Symlin (in combination with insulin) lowered their HbA1c results by 0.57 percent, on average, while people taking insulin alone decreased their HbA1c results by only 0.17 percent. Similar results were seen in people who had type 1 diabetes.
Studies have shown that the higher the HbA1c, the greater the chance of developing long-term problems related to diabetes. This includes problems such as:
By getting blood sugar levels under control with Symlin, it may be possible to decrease the chances of developing these diabetes-related complications.
In one study, people taking Symlin and insulin lost 3.3 pounds, on average (over six months), while people taking insulin alone gained about half a pound, on average. Similar results were seen in people with type 1 and type 2 diabetes.
Symlin has been shown to reduce the amount of insulin a person needs to take. In one study in people with type 2 diabetes, people taking the drug were able to reduce their doses of both meal-time insulin and long-acting insulin, while people taking insulin alone needed to increase both meal-time and long-acting insulin doses.