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Starlix Warnings and Precautions

Starlix warnings and precautions include the risk of low blood sugar, the potential for allergic reactions, and the danger of taking the medication while pregnant. People who have type 1 diabetes or diabetic ketoacidosis should not take the drug. Starlix warnings and precautions also extend to those who have kidney or liver problems, pituitary gland problems, or certain allergies.

Starlix: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Starlix® (nateglinide) if you have:
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Will be having surgery.
Tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Starlix Warnings and Precautions

Warnings and precautions to be aware of prior to taking Starlix include the following:
  • Starlix can cause low blood sugar (hypoglycemia), a potentially dangerous condition. To reduce this risk, the medication should be taken only before meals. If you skip a meal, you should also skip your dose of Starlix.
Low blood sugar is more common in elderly people and in people with adrenal, pituitary, liver, or kidney problems, as well as during fasting before surgery and after prolonged exercise. Symptoms of low blood sugar may include:
    • Irritability
    • Trembling
    • Cold sweats
    • Blurry vision.
(Click Starlix and Blood Sugar for more information.)
  • Fever, infections, injury, or surgery can temporarily increase blood sugar, even in people with well-controlled diabetes. Starlix may not be enough to treat diabetes at these times, and the use of insulin may be required. Contact your healthcare provider if you have a fever, infection, injury, or will be having surgery. Also, make sure you know the symptoms of high blood sugar and how to check your blood sugar levels.
  • Starlix has not been studied in people with moderate or severe liver disease, including liver failure or cirrhosis. Therefore, if you have liver disease, talk with your healthcare provider before taking Starlix.
  • Starlix can interact with certain medications (see Starlix Drug Interactions).
  • Starlix is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy. Talk to your healthcare provider if you become pregnant or are thinking about becoming pregnant while taking the drug (see Starlix and Pregnancy).
  • It is not known if Starlix passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider.
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