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Available by prescription only, sitagliptin/simvastatin is a drug used to treat high cholesterol in people with type 2 diabetes. This tablet contains two active ingredients, one that helps to control blood sugar levels and one that helps to lower cholesterol. Although this can be an effective medicine, it may not be suitable for some people who are taking certain medications or who have certain medical conditions.

In September 2013, Merck & Co, Inc., announced that it would be discontinuing this medication. It is clear that this decision was made for business reasons, not for safety reasons.

What Is Sitagliptin/Simvastatin?

Sitagliptin/simvastatin (Juvisync®) is a prescription combination medication. It contains sitagliptin (Januvia®), a type 2 diabetes medication, and simvastatin (Zocor®), a "statin" cholesterol medication.
(Click What Is Sitagliptin/Simvastatin Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, sitagliptin/simvastatin may cause side effects. However, not everyone who takes the drug will experience problems. In fact, most people tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common. If side effects do occur, most people do not need to stop taking this medicine.
Common side effects of sitagliptin/simvastatin include but are not limited to:
  • Upper respiratory tract infections, such as the common cold
  • Headaches
  • Bronchitis
  • Abdominal (stomach) pain.
Keep in mind that if you experience unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or a feeling of illness, it is important to contact your healthcare provider immediately. This could be a sign of a serious, life-threatening muscle problem (see Juvisync and Muscle Pain for more information).
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Sitagliptin/Simvastatin Drug Information

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