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Drug Interactions

Sitagliptin/simvastatin may react with a number of other medications (see Drug Interactions With Sitagliptin/Simvastatin for more information).

What If I Overdose on Sitagliptin/Simvastatin?

If you happen to overdose on sitagliptin/simvastatin, seek immediate medical attention (see Juvisync Overdose for more information).

What If I Miss a Dose of This Medicine?

If you do not take your dose as scheduled, take it as soon as you remember, unless it is almost time for your next scheduled dose. If it is almost time for your next dose, skip the one you missed and take your next dose instead. Do not take a double dose.

How Does It Work?

Sitagliptin/simvastatin is a combination of sitagliptin and simvastatin. Sitagliptin belongs to a class of diabetes medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones.
As a DPP-4 inhibitor, sitagliptin slows down the breakdown of incretin hormones, increasing the level of these hormones in the body. It is this increase in incretin hormones that is responsible for the beneficial actions of sitagliptin, such as increasing insulin production in response to meals and decreasing the amount of glucose (sugar) that the liver produces.
Because incretin hormones are more active in response to higher blood sugar levels (and are less active in response to low blood sugar), the risk of dangerously low blood sugar (hypoglycemia) is low with sitagliptin.
Simvastatin is part of a class of drugs called statins. It works by blocking a particular enzyme (HMG-CoA reductase) that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. It also increases the liver's ability to collect and get rid of LDL cholesterol.
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Sitagliptin/Simvastatin Drug Information

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