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Sitagliptin/Simvastatin Dosage

Before prescribing a specific dose of sitagliptin/simvastatin, your healthcare provider will take into consideration other medical conditions you have, other medications you are taking, and various other factors. This combination medication comes as a tablet that is taken once a day in the evening. If you are taking certain other medications, you may need a lower sitagliptin/simvastatin dosage.

In September 2013, Merck & Co, Inc., announced that it would be discontinuing this medication. It is clear that this decision was made for business reasons, not for safety reasons.

An Introduction to Your Dosage of Sitagliptin/Simvastatin

The dosage of sitagliptin/simvastatin (Juvisync®) your healthcare provider recommends will vary, depending on a number of factors, including:
As is always the case, do not adjust your dosage unless specifically told to do so by your healthcare provider.

Sitagliptin/Simvastatin Dosing Guidelines

The recommended starting dose of sitagliptin/simvastatin for most people with high cholesterol is 100/40 mg, taken once a day in the evening. If you were already taking simvastatin, you can start at the same simvastatin dosage. For instance, if you were taking 20 mg of simvastatin, you can switch to sitagliptin/simvastatin 100/20 mg once daily.
Some of the medications that interact with simvastatin in such a way as to require lower-than-usual sitagliptin/simvastatin dosages include:
No dosage adjustment is required for people with mild kidney disease. People with moderate kidney disease need a lower-than-usual dosage of the sitagliptin component. For people with moderate kidney disease, this medication comes in strengths with half as much sitagliptin (only 50 mg, instead of 100 mg), along with the normal strengths of simvastatin (10, 20, or 40 mg). The drug is not recommended at all for people with severe kidney disease.
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Sitagliptin/Simvastatin Drug Information

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