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Side Effects of Sitagliptin/Simvastatin

Some of the most commonly reported side effects of sitagliptin/simvastatin include a runny or stuffy nose, a sore throat, and abdominal (stomach) pain. While reactions such as these are typically minor, there are some potentially serious complications that require immediate medical treatment. For example, contact your healthcare provider immediately if you develop muscle pain, tenderness, or weakness, particularly if it is combined with a fever.

In September 2013, Merck & Co, Inc., announced that it would be discontinuing this medication. It is clear that this decision was made for business reasons, not for safety reasons.
 

An Introduction to Side Effects of Sitagliptin/Simvastatin

Just like any medicine, sitagliptin/simvastatin (Juvisync®) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
 
When taking sitagliptin/simvastatin, if you experience unexplained muscle pain, tenderness, or weakness (especially if accompanied by a fever or feeling of illness), it is important to contact your healthcare provider immediately.
 
(This article covers many, but not all, of the possible side effects with sitagliptin/simvastatin. Your healthcare provider can discuss a more complete list with you.)
 

Serious Sitagliptin/Simvastatin Side Effects

Some side effects of sitagliptin/simvastatin are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Muscle pain, tenderness, or weakness, especially if you also have a fever or feel ill, as these may be signs of a serious breakdown of muscle, known as rhabdomyolysis (see Juvisync and Muscle Pain)
  • Significant, unexplained changes in the amount of urine you produce, which may be a sign of kidney problems
  • Signs of liver damage (see Juvisync and Liver Damage), such as:
 
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Upper-right abdominal (stomach) pain
    • Dark urine
    • High liver enzymes (found using a blood test)
 
 
    • Nausea
    • Vomiting
    • Loss of appetite
    • Severe, persistent abdominal (stomach) pain that sometimes radiates to the back
 
  • Signs of an allergic reaction, such as:
 
    • A rash
    • Itching
    • Joint pain
    • Anemia
    • Low white blood cell counts
    • Sensitivity to the sun
    • Fever and chills
    • Flushing
    • A general ill feeling
    • Hives
    • Wheezing
    • Difficulty breathing
    • Swelling of the mouth, tongue, or throat.
 
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Sitagliptin/Simvastatin Drug Information

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