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Side Effects of Sitagliptin/Simvastatin

Common Side Effects

Sitagliptin/simvastatin contains two separate medications, and it was approved based on information known for those two separate medications. Therefore, at this time, the available information on possible side effects of sitagliptin/simvastatin is actually just information about the two drugs used individually (not in combination).
For the sitagliptin component, the only commonly reported side effects were a stuffy/runny nose and sore throat (common cold symptoms), which occurred in 5.2 percent of people.
Simvastatin has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking simvastatin were documented and compared to the side effects that occurred in a similar group of people who were taking a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the group taking the placebo.
In these studies, common simvastatin side effects included:
  • Bronchitis -- in up to 6.6 percent of people
  • Abdominal (stomach) pain -- up to 5.9 percent
  • Atrial fibrillation (an irregular heart rhythm) -- up to 5.7 percent
  • Stomach irritation (gastritis) -- up to 4.9 percent
  • Eczema -- up to 4.5 percent
  • A spinning sensation (vertigo) -- up to 4.5 percent
  • Diabetes -- up to 4.2 percent
  • Insomnia -- up to 4 percent.

Final Thoughts

You may experience some or none of the sitagliptin/simvastatin side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while taking this medication, or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
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Sitagliptin/Simvastatin Drug Information

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