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Drug Interactions With Sitagliptin/Simvastatin

Certain antibiotics, antifungals, and other drugs may cause negative interactions when combined with sitagliptin/simvastatin. Some of these reactions can increase the risk for serious side effects, including a potentially life-threatening breakdown of muscles. Your healthcare provider may need to monitor you more closely if you are undergoing treatment with this medicine, and adjust your dosage amounts as needed.

In September 2013, Merck & Co, Inc., announced that it would be discontinuing this medication. It is clear that this decision was made for business reasons, not for safety reasons.
 

An Overview of Sitagliptin/Simvastatin Interactions

Sitagliptin/simvastatin (Juvisync®) is a prescription cholesterol medication. Because sitagliptin/simvastatin contains two different medications, it has the potential to react with quite a few other medications. Some of the drugs that may interact with sitagliptin/simvastatin include but are not limited to:
 
 
 
  • Certain antifungals, such as:
  •  
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Posaconazole (Noxafil®)
    • Voriconazole (Vfend®)
 
 
 
 

 

 
Some of these sitagliptin/simvastatin interactions may increase your risk for developing serious muscle problems (see Juvisync and Muscle Pain). If you are taking sitagliptin/simvastatin and experience unexplained muscle pain, tenderness, or weakness (especially if they are accompanied by a fever or feeling of illness), it is important to contact your healthcare provider immediately.
 
Type 2 Diabetes: Fact or Fiction

Sitagliptin/Simvastatin Drug Information

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