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What Is Sitagliptin and Metformin Used For?

What is sitagliptin and metformin used for? The combination drug -- available by prescription -- is used for the treatment of type 2 diabetes. It is only approved for use in adults because it has not been adequately studied in children. At this time, there are no other conditions that sitagliptin and metformin is used for.

What Is Sitagliptin and Metformin Used For? -- An Overview

Sitagliptin and metformin (Janumet®) is a prescription medication that is used to treat type 2 diabetes (also known as non-insulin-dependent diabetes or adult-onset diabetes). It is a combination medication, containing, as the name implies, sitagliptin (Januvia®) and metformin (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®). The medication is typically used when blood sugar cannot be adequately controlled by sitagliptin or metformin alone.

Sitagliptin and Metformin Uses for Type 2 Diabetes

Type 2 diabetes is the most common form of diabetes (see Diabetes Types). It is a condition in which the cells do not respond to insulin as well as they normally should. As a result, the cells do not take sugar out of the blood very well. This is why people with type 2 diabetes have high blood sugar.
Over time, high blood sugar can lead to a number of problems, including:
The cause of type 2 diabetes is not fully understood, although it is known that obesity and genetics play important roles.
Sitagliptin and metformin, as mentioned, contains two different diabetes medications. Sitagliptin is part of a class of diabetes medication called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones. As a DPP-4 inhibitor, the combination drug slows down the breakdown of incretin hormones, increasing the level of these hormones in the body. This increase is responsible for the beneficial actions of the medication, including increasing insulin production in response to meals and decreasing the amount of glucose (sugar) that the liver produces.
Metformin is part of a class of diabetes medication known as biguanide medication. It works in several ways. It decreases the amount of sugar (glucose) made by the liver, decreases the amount of sugar absorbed into the body from the diet, and makes insulin receptors more sensitive, helping the body respond to its own insulin better. All of these effects cause a decrease in blood sugar levels and a better control of blood sugar.
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Sitagliptin and Metformin (Janumet)

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