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Sitagliptin and Metformin Dosing

When you first start taking a combination diabetes medication like sitagliptin and metformin, dosing is based on your existing dose of metformin or sitagliptin. It may also be affected by other medications you are taking or other medical conditions that are present. If needed, your healthcare provider can gradually increase your sitagliptin and metformin dosage up to 50 mg/1000 mg, taken twice a day.

An Introduction to Sitagliptin and Metformin Dosing

The dose of sitagliptin and metformin (Janumet®) that your healthcare provider recommends will vary, depending on a number of factors, including:
  • How well your diabetes is controlled
  • Other medical conditions you may have
  • Other medications you may currently be taking.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Sitagliptin and Metformin Dosing for Type 2 Diabetes

Sitagliptin and metformin is a combination medication containing, as the name implies, sitagliptin (Januvia®) and metformin (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®), and is intended to be used in people whose blood sugar is not adequately controlled by sitagliptin or metformin alone. The recommended starting dose of the combination drug depends on your current dose of metformin or sitagliptin. Your healthcare provider may slowly increase your dosage, if needed, up to a maximum of 50 mg/1000 mg, taken twice daily.

General Information on Dosing With Sitagliptin and Metformin

Considerations for people taking sitagliptin and metformin include the following:
  • The medication comes in tablet form. It should be taken by mouth twice a day.
  • The medication should be taken with food.
  • Sitagliptin and metformin should be taken at the same time(s) each day to maintain an even level in your blood.
  • For the combination drug to work properly, you have to take it as prescribed. Sitagliptin and metformin will not work if you take it differently from how your healthcare provider recommends.
If you are unsure about anything related to sitagliptin and metformin or sitagliptin and metformin dosing, talk to your doctor, nurse, or pharmacist. Do not stop taking the medication without first discussing it with your healthcare provider.
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Sitagliptin and Metformin (Janumet)

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