Drug Interactions With Sitagliptin and Metformin

Several medicines may cause drug interactions with sitagliptin and metformin, including cimetidine, certain decongestants, oral contraceptives, and calcium channel blockers. When you take the diabetes medication with these drugs, your risk of high blood sugar increases. To minimize the risk of developing sitagliptin and metformin drug interactions, tell your healthcare provider about all the medicines you are currently taking.

 

Drug Interactions With Sitagliptin and Metformin: An Overview

 Sitagliptin and metformin (Janumet®) may potentially interact with a number of other medicines. Some of these medicines that may lead to drug interactions with sitagliptin and metformin include:
 
  • Certain decongestants, such as phenylephrine (Sudafed PE®) or psuedoephedrine (Sudafed®)
     
  • Calcium channel blockers, such as:
o Betamethasone (Celestone®)
o Cortisone
o Dexamethasone (Decadron®)
o Fludrocortisone (Florinef®)
o Hydrocortisone (Cortef®)
o Methylprednisolone (Depo-Medrol®, Medrol®)
o Prednisolone (Ovapred®, Pediapred®)
o Triamcinolone (Kenalog®, Aristospan®)
  • Digoxin (Digitek®, Lanoxin®)
     
  • Diuretics, such as:
o Acetazolamide (Diamox®)
o Chlorthalodone
o Promethazine (Phenergan®)
(Drug Interactions With Sitagliptin and Metformin Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;