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Drug Interactions With Sitagliptin and Metformin

Oral Contraceptives
Taking sitagliptin and metformin with oral contraceptives (birth control pills) can make sitagliptin and metformin less effective, possibly increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
Combining sitagliptin and metformin with phenothiazines can make sitagliptin and metformin less effective, possibly increasing your risk of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin dose, especially when starting or stopping a phenothiazine.
 
Phenytoin
Taking sitagliptin and metformin with phenytoin can make sitagliptin and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin dose, especially when starting or stopping a phenytoin.
 
Thyroid Medications
If sitagliptin and metformin is combined with thyroid medications, it can make sitagliptin and metformin less effective, possibly increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin dose, especially when starting or stopping a thyroid medication.
 

Final Thoughts on Drug Interactions With Sitagliptin and Metformin

It is possible that not all drug interactions with sitagliptin and metformin were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you.
 
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