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Drug Interactions With Sitagliptin and Metformin

Sitagliptin and Metformin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when sitagliptin and metformin is combined with any of the drugs listed above.
 
Certain Decongestants
Taking sitagliptin and metformin with certain decongestants can make sitagliptin and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). Decongestants are in many cough and cold products, so be sure to talk to your healthcare provider before taking any cough or cold medications during treatment with sitagliptin and metformin.
 
Calcium Channel Blockers
Combining sitagliptin and metformin with calcium channel blockers can make sitagliptin and metformin less effective, potentially increasing your risk of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin dose, especially when starting or stopping a calcium channel blocker.
 
However, taking sitagliptin and metformin with nifedipine (a calcium channel blocker) can increase the level of sitagliptin and metformin in your blood. Your healthcare provider may need to adjust your dose of sitagliptin and metformin to prevent this interaction from occurring.
 
Cimetidine
If sitagliptin and metformin is taken with cimetidine, it can increase the level of sitagliptin and metformin in your blood, increasing your risk of side effects. Your healthcare provider may need to adjust your dose of these medications or suggest an alternative to cimetidine, depending on your particular situation.
 
Corticosteroids
Taking sitagliptin and metformin with corticosteroids can make sitagliptin and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin dose, especially when starting or stopping a corticosteroid.
7 Signs of High Blood Sugar

Sitagliptin and Metformin (Janumet)

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