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Prandin Warnings and Precautions

Prandin warnings and precautions include the risk of low blood sugar, potential allergic reactions, and the danger of taking the medication while pregnant. People who have kidney or liver problems, pituitary gland problems, or certain allergies should not take the drug. Prandin warnings and precautions also extend to people with type 1 diabetes or diabetic ketoacidosis.

Prandin: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Prandin® (repaglinide) if you have:
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Will be having surgery.
Tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Prandin Warnings and Precautions

Warnings and precautions to be aware of before taking Prandin include the following:
  • Prandin can cause low blood sugar (hypoglycemia), which can be dangerous. To reduce this risk, the drug should be taken only before meals. If you skip a meal, you should also skip your Prandin dosage. This is more common in elderly people and in people with adrenal, pituitary, liver, or kidney problems, as well as during fasting before surgery and after prolonged exercise.
  • Prandin is not licensed to be used with NPH insulin (Humulin® or Novolin N®). In studies, there were reports of heart problems (including heart attacks) in people who took both Prandin and NPH insulin.
  • Fever, infections, injury, or surgery can temporarily increase your blood sugar, even in people with well-controlled diabetes. Prandin may not be enough to treat your diabetes at these times, and the use of insulin may be required. Contact your healthcare provider if you have a fever, infection, injury, or will be having surgery. Also, make sure you know the symptoms of high blood sugar and how to check your blood sugar levels (see Prandin and Blood Sugar). Symptoms may include irritability, trembling, cold sweats, or blurry vision, among other things.
  • Prandin can interact with certain medications (see Prandin Drug Interactions).
  • Prandin is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy. Talk to your healthcare provider before using this drug during pregnancy (see Prandin and Pregnancy).
  • It is not known if Prandin passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider before taking Prandin.
Healthy Eating for People With Diabetes

Prandin (Repaglinide)

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