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Drug Interactions

Prandin can potentially interact with a number of medicines (see Prandin Drug Interactions).

What Should I Tell My Healthcare Provider Before Taking Prandin?

You should talk with your healthcare provider prior to taking this medication if you have:
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • An upcoming surgery
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Prandin Warnings and Precautions to learn more, including information on who should not take the drug.)


In general, treatment for type 2 diabetes begins with lifestyle changes (for example, weight loss, exercise, and diet). If lifestyle changes alone are not effective in managing diabetes, medication such as Prandin may be necessary.
The main goal of diabetes medication is to lower blood sugar levels enough to reduce the risk of developing problems related to diabetes, such as heart, nerve, eye, or kidney problems. Because Prandin can lower blood sugar levels, people may be able to lower their risk of developing problems related to high blood sugar by taking it.
Prandin is usually quite effective in controlling blood sugar. It is also generally well tolerated. However, side effects can occur, or the medicine may not work as well as needed. In these cases, Prandin may need to be combined with another diabetes medicine, such as metformin (Glucophage®) or insulin. You may also wish to consider a substitute for Prandin. These can include another meglitinide or diabetes drugs, either by themselves or in combination.
(Click Prandin Alternatives to learn more.)
To learn about controlling diabetes through lifestyle choices, click the following eMedTV links:
Diabetes Tips for Seniors

Prandin (Repaglinide)

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