PrandiMet Interactions

The following sections explain in detail the potentially negative interactions that can occur when PrandiMet is combined with any of the drugs listed above.

 

Theoretically, amiloride may affect the ability of the kidneys to filter metformin (one of the components of PrandiMet) from the blood, possibly leading to high levels of metformin. Your healthcare provider may need to monitor you more closely if you take these medications together.

 

Taking PrandiMet with atazanavir can significantly increase the level of repaglinide (one of the components of PrandiMet) in your blood, increasing your risk of side effects (especially dangerously low blood sugar). Talk to your healthcare provider before taking these two medications together.

 

Taking PrandiMet with certain antibiotics or antifungals can increase the level of PrandiMet in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your dose of PrandiMet while you are taking antibiotics or antifungals. You should not take PrandiMet if you are also taking itraconazole and gemfibrozil (a cholesterol medication), as it could cause dangerously high levels of PrandiMet in the blood.

 

Cimetidine may affect the ability of the kidneys to filter metformin (one of the components of PrandiMet) from the blood, possibly leading to high levels of metformin. Your healthcare provider may need to monitor you more closely if you take these medications together.

 

Taking PrandiMet with delavirdine can increase the level of repaglinide (one of the components of PrandiMet) in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of PrandiMet if you are taking these two medications together.