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PrandiMet Dosage

Your PrandiMet dosage will depend on how well your diabetes is controlled, other medical conditions you may have, and other medications you are taking. If your diabetes is not adequately controlled, your healthcare provider may slowly increase the dose as necessary (increasing the dose quickly increases the risk of side effects). The maximum dose of PrandiMet is 10 mg/2500 mg total per day, and the maximum dose per meal is 4 mg/1000 mg.

Dosage of PrandiMet: An Introduction

PrandiMet™ (repaglinide and metformin) is a combination of two different diabetes drugs: repaglinide (Prandin®) and metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®). The PrandiMet dose that your healthcare provider recommends will vary depending on a number of factors, including:
 
  • How well your diabetes is controlled
  • Other medications you are taking
  • Any other medical conditions you may have.
     
As is the case with any medication, do not adjust your PrandiMet dosage unless your healthcare provider specifically instructs you to do so.
 

PrandiMet Dose for People Switching From Metformin

For people switching to PrandiMet from metformin (Fortamet, Glucophage, Glucophage XR, Glumetza, or Riomet), the recommended starting PrandiMet dose is 1 mg/500 mg twice daily with meals. If necessary to control your diabetes, your healthcare provider may increase your dose slowly (increasing the dose quickly increases the risk of dangerously low blood sugar).
 

PrandiMet Dosing for People Switching From Prandin

For people switching to PrandiMet from Prandin (repaglinide), the PrandiMet dose depends on the current Prandin dose. Keeping the dose of the repaglinide component as similar as possible, the starting dose should be either PrandiMet 1 mg/500 mg or 2 mg/500 mg twice a day. If necessary to control your diabetes, your healthcare provider may increase your dose slowly (increasing the dose quickly increases the risk of nausea, diarrhea, or other digestive side effects).
 
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