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Side Effects of Pioglitazone and Metformin XR

Common Side Effects

The side effect data from the prescribing information ("package insert") for pioglitazone and metformin XR was taken from clinical trials in which a combination of pioglitazone and immediate-release metformin was used. Since pioglitazone and metformin XR contains pioglitazone plus extended-release metformin, it is possible that the exact percentages might differ. Nonetheless, this data provides a general picture of the side effects that can be expected with pioglitazone and metformin XR.
Based on these studies, the most common side effects of pioglitazone plus immediate-release metformin included:
  • Upper respiratory tract infections (similar to the common cold or flu) -- in up to 13.5 percent of people
  • Swelling or fluid retention (edema) of the lower leg or ankles -- up to 11.3 percent
  • Weight gain -- up to 6.7 percent (see Actoplus Met XR and Weight Gain)
  • Diarrhea -- up to 5.8 percent
  • Nausea -- up to 5.8 percent
  • Urinary tract infections (UTIs), including bladder infections -- up to 5.8 percent
  • Dizziness -- up to 5.4 percent
  • Headache -- up to 5.3 percent
  • Sinus infection or irritation -- up to 5 percent.

Final Thoughts

You may experience some or none of the pioglitazone and metformin XR side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while taking the drug or if something "just does not seem right." While it may not be related to pioglitazone and metformin XR, your healthcare provider will be able to diagnose and treat the problem.
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Pioglitazone and Metformin XR Information

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