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Precautions and Warnings With Pioglitazone and Metformin XR

If you have severe liver or kidney disease -- or even if your kidneys don't function as well as they should -- you may not be able to use pioglitazone and metformin XR. Warnings and precautions also apply to people who will be undergoing surgery or a medical procedure that uses contrast dye, as well as women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking pioglitazone and metformin XR (Actoplus Met® XR) if you have:
  • Low vitamin B12 levels (pernicious anemia)
  • Kidney problems, including kidney failure (renal failure)
  • An upcoming surgery or procedure, including x-rays and other radiology procedures
  • Heart problems of any kind, especially congestive heart failure (CHF)
  • A history of heart attack or stroke
  • Liver problems, including liver failure or cirrhosis
  • Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Are having problems getting pregnant
  • Are premenopausal without regular menstrual periods
  • Drink alcohol.
In addition, tell your healthcare provider about all other medicines you may be taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
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Pioglitazone and Metformin XR Information

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