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Pioglitazone and Metformin XR

How Does Pioglitazone and Metformin XR Work?

The two different medications in pioglitazone and metformin XR work differently and have different effects in the body:
 
  • Metformin works in several ways. It decreases the amount of sugar (glucose) made by the liver. Metformin can also decrease the amount of sugar absorbed into the body from the diet and can make insulin receptors more sensitive, helping the body respond to its own insulin better. All of these effects cause a decrease in blood sugar levels.
     
  • Pioglitazone is part of a class of diabetes medications called thiazolidinediones (or sometimes called "glitazones"). This drug helps to improve insulin sensitivity. This means that pioglitazone helps your body respond to natural insulin better, which helps to lower blood sugar.
     
Because pioglitazone and metformin XR does not increase the amount of insulin the body produces, it is less likely to cause dangerously low blood sugar (hypoglycemia), which many other diabetes drugs can do.
 

When and How to Take It

General considerations to keep in mind during treatment with pioglitazone and metformin XR include the following:
 
  • The medicine comes in tablet form. It should be taken by mouth, usually once a day with the evening meal.
  • It is best to take pioglitazone and metformin XR with food in order to prevent stomach upset.
  • Pioglitazone and metformin XR should be taken at the same time each day to maintain an even level in your blood.
  • Be sure to swallow the tablets whole. Do not break, chew, or crush them, as this will cause too much medication to be released too quickly.
  • Each tablet has a tiny hole in it. This is normal and is part of the extended-release mechanism.
  • For this product to work properly, it must be taken as prescribed. It will not work if you stop taking it.
     
Healthy Eating for People With Diabetes

Pioglitazone and Metformin XR Information

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