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Pioglitazone and Metformin XR Dosage

Your healthcare provider will take several things into account when prescribing a dose of pioglitazone and metformin XR. This includes how well your diabetes is controlled right now and any other medical conditions you have. The medication is a tablet that is taken by mouth once a day, preferably with the evening meal.

An Introduction to Dosing With Pioglitazone and Metformin XR

Pioglitazone and metformin XR (Actoplus Met® XR) is a combination of two different diabetes medications: pioglitazone hydrochloride (Actos®) and extended-release metformin hydrochloride. The pioglitazone and metformin XR dosage your healthcare provider prescribes will vary, depending on a number of factors, including:
 
  • How well your diabetes is controlled
  • Other medical conditions you may have
  • Other medications you are currently taking.
     
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Pioglitazone and Metformin XR Dosage for Diabetes

If you are switching to pioglitazone and metformin XR from pioglitazone (Actos), the recommended starting dose is pioglitazone and metformin XR 15 mg/1000 mg once a day or pioglitazone and metformin XR 30 mg/1000 mg once a day. If necessary, your healthcare provider may gradually increase this amount up to a maximum of pioglitazone and metformin XR 45 mg/2000 mg once per day.
 
Even if you take two tablets to achieve the correct pioglitazone and metformin XR dosage, you should take them at the same time (typically with the evening meal), and not split them up throughout the day.
 

General Information on Taking Pioglitazone and Metformin XR

Considerations to keep in mind during treatment with pioglitazone and metformin XR include the following:
 
  • It is best to try to take pioglitazone and metformin XR with food in order to prevent stomach upset.
     
  • This medication should be taken at the same time each day to maintain an even level in your blood.
     
  • Be sure to swallow the tablets whole. Do not break, chew, or crush them, as this will cause too much medication to be released too quickly.
     
  • Each tablet has a tiny hole in it. This is normal and is part of the extended-release mechanism. Also, you may see tablet shells in your stool. This is also normal, as the shell does not dissolve.
     
  • For pioglitazone and metformin XR to work properly, it must be taken as prescribed. It will not work if you stop taking it.
     
  • If you are unsure about anything related to dosing with pioglitazone and metformin XR, talk to your doctor, nurse, or pharmacist. Do not stop taking this drug without first discussing it with your healthcare provider.
     
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Pioglitazone and Metformin XR Information

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