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Drug Interactions With Pioglitazone and Metformin XR

Rifampin or Rifapentine
Taking pioglitazone and metformin XR and rifampin or rifapentine together can decrease the level of pioglitazone and metformin XR in your blood, perhaps making it less effective. Your healthcare provider may need to increase your dose of pioglitazone and metformin XR to prevent this drug interaction from occurring.
 
Ritonavir
If pioglitazone and metformin XR and ritonavir are taken together, this can increase the level of pioglitazone and metformin XR in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of pioglitazone and metformin XR to prevent this interaction.
 
Thyroid Medications
Combining pioglitazone and metformin XR and thyroid medications can make pioglitazone and metformin XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin XR dose, especially when starting or stopping a thyroid medication.
 

Final Thoughts

It is possible that not all pioglitazone and metformin XR drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
Healthy Eating for People With Diabetes

Pioglitazone and Metformin XR Information

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