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Drug Interactions With Pioglitazone and Metformin XR

Cimetidine
Combining pioglitazone and metformin XR with cimetidine can increase the level of pioglitazone and metformin XR in your blood, possibly increasing your risk of side effects. Your healthcare provider may adjust your dose of these medications or suggest an alternative to cimetidine, depending on your particular situation.
 
Corticosteroids
Taking pioglitazone and metformin XR with corticosteroids can make pioglitazone and metformin XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin XR dose, especially when starting or stopping a corticosteroid.
 
Diuretics
If pioglitazone and metformin XR is taken with diuretics, this can make pioglitazone and metformin XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin XR dose, especially when starting or stopping a diuretic.
 
If pioglitazone and metformin XR is combined with furosemide (a diuretic), this can affect the levels of both medications in your blood. This may increase your risk of pioglitazone and metformin XR side effects and make furosemide less effective. To prevent this drug interaction, your healthcare provider may need to adjust your dose of these medications.
 
Estrogens
Taking pioglitazone and metformin XR with estrogens can make pioglitazone and metformin XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin XR dose, especially when starting or stopping an estrogen.
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Pioglitazone and Metformin XR Information

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