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Drug Interactions With Pioglitazone and Metformin XR

More Information on Drug Interactions With Pioglitazone and Metformin XR

The following sections explain in detail the potentially negative interactions that can occur when pioglitazone and metformin XR is combined with any of the drugs listed above.
 
Atazanavir
Taking pioglitazone and metformin XR with atazanavir can increase the level of pioglitazone and metformin XR in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your pioglitazone and metformin XR dosage to prevent this drug interaction from occurring.
 
Atorvastatin
In studies, when pioglitazone and metformin XR and atorvastatin were taken together, this decreased the levels of both medications in the blood, perhaps making them both less effective. Your healthcare provider may need to adjust your doses of these drugs if both have been prescribed.
 
Calcium Channel Blockers
Combining pioglitazone and metformin XR with a calcium channel blocker can make pioglitazone and metformin XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely and your healthcare provider may need to adjust your pioglitazone and metformin XR dose, especially when starting or stopping a calcium channel blocker.
 
Certain Decongestants
If pioglitazone and metformin XR and certain decongestants are taken together, this can make pioglitazone and metformin XR less effective, increasing your chance of high blood sugar (hyperglycemia). Decongestants are in many cough and cold products, so talk to your healthcare provider or pharmacist before taking any cough or cold products if you are taking pioglitazone and metformin XR.
 
Certain Seizure Medications
Taking pioglitazone and metformin XR with certain seizure medications can decrease the level of pioglitazone and metformin XR in your blood, perhaps making it less effective. Your healthcare provider may need to increase your dose of pioglitazone and metformin XR to prevent this drug interaction from occurring.
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Pioglitazone and Metformin XR Information

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