As mentioned already, Oseni contains two diabetes medicines: alogliptin and pioglitazone. These two medicines work in different ways to control blood sugar.
Alogliptin belongs to a group of medicines known as dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down certain hormones known as incretin hormones. These hormones cause insulin to be released from the pancreas (which lowers blood glucose levels) in response to meals. They also reduce the amount of glucagon released by the pancreas, which reduces glucose (sugar) production by the liver.
By blocking the DPP-4 enzyme, Oseni increases the level of incretin hormones in the blood. This causes more insulin to be made in response to meals and reduces the amount of glucose made by the liver.
Pioglitazone belongs to a group of medicines known as thiazolidinediones, or simply "glitazones." Glitazones work by improving insulin sensitivity in muscle and fat tissue. This means it helps the cells in the body respond better to insulin, which lowers blood sugar. It also reduces the amount of glucose released by the liver.
Some general considerations to keep in mind during treatment with Oseni include the following:
- This medication comes in the form of a tablet. It is usually taken by mouth once a day.
- You can take this medication with food or on an empty stomach. Try taking it with food if it upsets your stomach.
- Do not crush, cut, or split Oseni tablets; they must be swallowed whole.
- Try to take your dose at about the same time each day to keep an even level of the drug in your bloodstream.
- For the medication to work properly, it must be taken as prescribed. Do not stop taking it or take a different dose unless your healthcare provider tells you to do so.