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Drug Interactions With NPH Insulin

NPH Insulin Interactions Explained

Any of the medications discussed in this article may increase the risk of low blood sugar when combined with NPH insulin (or any other insulin medications). Therefore, it is a good idea to check with your healthcare provider before you take any of these medications with NPH insulin. Your healthcare provider may recommend that you monitor your blood sugar levels more closely for a while to see if you need to adjust your NPH insulin dosage. In some cases, an alternative medication that does not interact with NPH insulin may be recommended.
 
It is also important to check with your healthcare provider any time you stop taking any of the medications listed in this article or any time your dose is adjusted. Again, you may need to monitor your blood sugar levels more closely for a while, and your healthcare provider may need to adjust your dose of NPH insulin.
 
For the thiazolidinediones (TZDs), there is an additional type of drug interaction that may occur. TZDs can cause fluid retention, possibly causing or worsening serious problems such as heart failure. Insulin may increase these risks. 
 

Final Thoughts on Drug Interactions With NPH Insulin

Many NPH insulin drug interactions were not discussed in this article, including interactions that may cause high blood sugar (hyperglycemia). These interactions are usually not dangerous, although they may become dangerous if they are not treated. In these cases, you may need to have your NPH insulin dosage adjusted. It is a good idea to get into the practice of checking with your healthcare provider any time you start, stop, or change the dose of any medication, including non-prescription medications.
 
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NPH Insulin Information

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