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NovoLog Mix 50/50 Drug Interactions

If certain medications are taken in combination with NovoLog Mix 50/50, drug interactions could occur that may result in dangerously low blood sugar levels. Some of these medications include beta blockers, ACE inhibitors, sulfonamide antibiotics, and monoamine oxidase inhibitors (MAOIs). To help prevent these potentially serious interactions, alert your healthcare provider when you start, stop, or change the dose of any medication.

NovoLog Mix 50/50 Interactions: An Overview

Insulin medications, including NovoLog® Mix 50/50 (insulin aspart protamine/insulin aspart), can potentially interact with numerous medications, too many to list entirely in this article. Essentially, any medication that has the potential to increase or decrease blood sugar might interact with NovoLog Mix 50/50. Some interactions (which are not discussed in this article) may increase blood sugar levels, which is not healthy but usually not dangerous right away.
Other NovoLog Mix 50/50 drug interactions can result in dangerously low blood sugar levels (known medically as hypoglycemia). Some of the medicines that may cause dangerously low blood sugar when combined with NovoLog Mix 50/50 include:
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors), such as:










    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)


  • Sulfonamide antibiotics ("sulfa drugs"), such as:


    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)


Healthy Eating for People With Diabetes

NovoLog Mix 50/50 Insulin

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