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Metformin Drug Interactions

Metformin Interactions Explained

 
Certain Decongestants
Taking metformin with certain decongestants can make metformin less effective, increasing your chance of high blood sugar (hyperglycemia). Decongestants are in many cough and cold products, so be sure to talk to your healthcare provider before taking any cough or cold products.
 
Calcium Channel Blockers
Taking metformin with calcium channel blockers can make metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your metformin dose, especially when starting or stopping a calcium channel blocker.
 
However, taking metformin with nifedipine (a calcium channel blocker) can also increase the level of metformin in your blood. Your healthcare provider may need to adjust your dose of metformin.
 
Cimetidine (Tagamet)
Taking metformin with cimetidine can increase the level of metformin in your blood, increasing your risk of side effects. Your healthcare provider may need to adjust your dose of these medications or may suggest an alternative to cimetidine.
 
Corticosteroids
Taking metformin with corticosteroids can make metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your metformin dose, especially when starting or stopping a corticosteroid.
 
Diuretics
Taking metformin with diuretics can make metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your metformin dose, especially when starting or stopping a diuretic.
 
Taking metformin with furosemide (a diuretic) can affect the levels of both furosemide and metformin in your blood. This may increase your risk of metformin side effects and may make furosemide less effective. Your healthcare provider may need to adjust your dose of these medications.
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