Alternatives to Metformin
Insulin and Other Injectable Diabetes Medications
There are a variety of different types of insulin and other injectable medications for type 2 diabetes, including:
- Incretin mimetics
- Amylin analogues.
There are a variety of insulins available, including short-, rapid-, long-, or intermediate-acting insulins.
There are four incretin mimetics available: exenatide (Byetta®), long-acting exenatide (Bydureon®), iraglutide (Victoza®), and dulaglutide (Trulicity™). They work by acting like the hormone incretin in the body, increasing insulin production and slowing digestion. Byetta is taken twice daily, while Victoza is taken once daily, and Bydureon and Trulicity are both taken just once a week. All are taken as an injection just under the skin (subcutaneous injection).
There is one amylin analogue available, called pramlintide (Symlin®). This medication works like the amylin hormone in the body, increasing insulin production, slowing digestion, decreasing the production of glucose by the liver, and reducing appetite.
A Summary of Alternatives to MetforminThere are several alternatives to metformin for type 2 diabetes, including lifestyle changes or other medications for diabetes. If metformin is not working for you or if it is causing bothersome side effects, ask your healthcare provider about trying an alternative to metformin.