Alternatives to Metformin

Incretin Mimetics
There is one incretin mimetic available, called exenatide (Byetta®). It works by acting like the incretin hormone in the body, increasing insulin production and slowing digestion.
 
Amylin Analogues
There is one amylin analogue available, called pramlintide (Symlin®). This medication works like the amylin hormone in the body, increasing insulin production, slowing digestion, decreasing the production of glucose by the liver, and reducing appetite.
 

A Summary of Alternatives to Metformin

There are several alternatives to metformin for type 2 diabetes, including lifestyle changes or other medications for diabetes. If metformin is not working for you or if it is causing bothersome side effects, ask your healthcare provider about trying an alternative to metformin.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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