Metaglip Drug Interactions

Metaglip drug interactions with other medications, such as beta blockers, calcium channel blockers, and oral contraceptives, can cause the body to metabolize the medications differently than intended and may lead to problems. For example, these interactions can increase your risk of side effects or increase your chance of high blood sugar. If Metaglip drug interactions are a concern, your healthcare provider may adjust your doses.

 

An Overview of Metaglip Drug Interactions

 Metaglip® (glipizide and metformin) can potentially interact with several medicines. Some of the medicines that can lead to Metaglip drug interactions include:
 
  • Beta blockers, such as:
 
 
 
 
  • Certain decongestants, such as phenylephrine (Sudafed PE®) or psuedoephedrine (Sudafed®)
     
  • Cimetidine (Tagamet®)
     
  • Corticosteroids, such as:
 
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®).
 
  • Diuretics, such as:
 
 
  • Estrogens
     
  • Isoniazid
     
  • Monoamine oxidase inhibitors (MAOIs), including:
 
 
  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
     
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
 
 
  • Probenecid (Benuryl®, ColBenemid®)
     
  • Salicylates, such as:
 
    • Aspirin
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®).
 
  • Sulfonamides ("sulfa drugs"), including:
 
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®).
 
  • Warfarin (Coumadin®, Jantoven®).
     
(Metaglip Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;