Diabetes Home > Symlin Side Effects

Although most people have no problems when taking Symlin, side effects can include nausea, a loss of appetite, and vomiting. In many cases, these side effects are minor and easily treated. However, some side effects of Symlin should be reported to your healthcare provider, such as severe nausea or vomiting, symptoms of low or high blood sugar, or signs of an allergic reaction.

An Introduction to Symlin Side Effects

As with any medicine, side effects are possible with Symlin® (pramlintide acetate). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. When side effects do occur, in most cases, they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Symlin. Your healthcare provider can discuss a more complete list of Symlin side effects with you.)

Common Side Effects of Symlin

Symlin has been studied thoroughly in clinical trials, in which the side effects of a group of people taking the drug are documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
Based on these studies, the most common side effects of Symlin include:
  • Nausea -- occurring in up to 48 percent of people
  • A loss of appetite or a decrease in food intake -- in up to 17 percent
  • Low blood sugar (hypoglycemia) -- in up to 16.8 percent (see Symlin and Blood Sugar)
  • Injury -- in up to 14 percent
  • Headaches -- in up to 13 percent
  • Vomiting -- in up to 11 percent
  • Abdominal pain (stomach pain) -- in up to 8 percent
  • Fatigue -- in up to 7 percent
  • Joint pain -- in up to 7 percent
  • Dizziness -- in up to 6 percent
  • Unexplained coughing -- in up to 6 percent
  • Allergic reactions -- in up to 6 percent
  • A sore throat -- in up to 5 percent.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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