Diabetes Home > PrandiMet

PrandiMet is a medication used to lower blood sugar levels in people with type 2 diabetes. Because it contains two different medications, it has different effects on the body. This prescription medication comes in tablet form and is taken two or three times daily before meals. Although most people tolerate this medication well, PrandiMet is not suitable for everyone. Potential side effects include nausea, diarrhea, and headaches.

What Is PrandiMet?

PrandiMet™ (repaglinide and metformin) is a prescription medication approved to treat type 2 diabetes. It is a combination of two different diabetes medications: repaglinide (Prandin®) and metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®).
 
(Click PrandiMet Uses for more information, including possible off-label uses.)
 

Who Makes PrandiMet?

PrandiMet is made by Novo Nordisk, Inc.
 

How Does It Work?

PrandiMet contains two different diabetes medicines. These two medications work differently and have the following effects in the body:
 
  • Repaglinide belongs to a group of diabetes medication called meglitinides. Meglitinides can lower blood sugar by helping the pancreas make more insulin. Another type of diabetes medication known as sulfonylureas (see PrandiMet Alternatives) also helps the pancreas make more insulin. However, unlike sulfonylureas, repaglinide is a short-acting medication and is generally used to lower blood sugar levels after meals.
     
  • Metformin works in several ways. It decreases the amount of sugar (glucose) made by the liver. This medication can also decrease the amount of sugar absorbed into the body (from the diet) and can make insulin receptors more sensitive, improving the way the body responds to its own insulin. All of these effects cause a decrease in blood sugar levels.
     
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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