Because one of the medications in PrandiMet (repaglinide and metformin) does pass through breast milk, make sure to talk to your healthcare provider before taking PrandiMet and breastfeeding. Although the metformin component in PrandiMet is usually considered compatible with breastfeeding, there is a possibility that the repaglinide component may increase the risk of skeletal deformities and low blood sugar levels in a breastfed infant.
Taking PrandiMet and Breastfeeding -- Is It Safe?
At least one of the components in PrandiMet™ (repaglinide and metformin) does pass through breast milk in humans. If you are breastfeeding a child, you should talk with your healthcare provider about taking PrandiMet.
What Does the Research Say?
Metformin (one of the components of PrandiMet) passes through breast milk in humans in relatively low amounts. In general, studies suggest that this does not pose a risk to the breastfed child. Metformin is usually considered compatible with breastfeeding.
Studies show that repaglinide (the other component of PrandiMet) passes through breast milk in rats. The chemical structure of repaglinide suggests that it probably will pass through breast milk in humans, although this has not yet been studied. When given to breastfeeding rats, repaglinide lowered the blood sugar in the breastfed pups and also seemed to increase the risk of skeletal deformities, although it is unknown if similar problems could occur in humans. In general, repaglinide is not considered compatible with breastfeeding, due to the risk of skeletal problems and low blood sugar levels in the infant.
Talking With Your Healthcare Provider About PrandiMet and Breastfeeding
You should talk with your healthcare provider about PrandiMet and breastfeeding. Each woman's situation is different, and you and your healthcare provider understand your situation best. After considering what you want and expect, as well as your current health situation, you and your healthcare provider can make a shared decision about PrandiMet and breastfeeding in your particular situation.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
PrandiMet [package insert]. Princeton, NJ: Novo Nordisk, Inc.;2012 March.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed July 21, 2008.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind.
Site users seeking medical advice about their specific situation should consult with their own physician. Click