Diabetes Home > NovoLog Drug Interactions

When certain medications are taken in combination with NovoLog, drug interactions could occur. While some interactions can increase blood sugar levels (which is not immediately dangerous), others can lead to low blood sugar (which can be extremely dangerous). Some of the medications that may cause potentially life-threatening NovoLog interactions include fibrate cholesterol medications, sulfonamide antibiotics, beta blockers, and oral diabetes medicines.

NovoLog Drug Interactions: An Overview

NovoLog® (insulin aspart) can potentially interact with numerous medications, too many to list entirely in this article. Some interactions (which are not discussed in this article) may increase blood sugar levels, which is not healthy but is usually not dangerous right away. Other NovoLog drug interactions can result in dangerously low blood sugar levels (hypoglycemia), which can be life-threatening. Some of the medicines that may cause dangerously low blood sugar when combined with NovoLog include:
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors), such as:







  • Monoamine oxidase inhibitors (MAOIs), such as:




    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)


  • Sulfonamide antibiotics ("sulfa drugs"), such as:


    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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