Diabetes Home > Nephrogenic Diabetes Insipidus

Nephrogenic diabetes insipidus is a type of diabetes that occurs when the kidneys stop filtering urine normally. It should not be confused with diabetes mellitus, a more common condition. Diagnosing this type of diabetes involves certain tests, such as urinalysis and a fluid deprivation test. If a diagnosis is confirmed, the patient may be given hydrochlorothiazide or indomethacin.

What Is Nephrogenic Diabetes Insipidus?

Nephrogenic diabetes insipidus is a medical condition that occurs when the kidneys stop filtering urine normally. This results in a person urinating large volumes of fluid and always being thirsty. Nephrogenic diabetes insipidus is one type of diabetes insipidus. Other types of diabetes insipidus include:
 

Diabetes Insipidus Versus Diabetes Mellitus

Diabetes insipidus (including nephrogenic diabetes insipidus) should not be confused with diabetes mellitus, which results from insulin deficiency or resistance, leading to high blood glucose. Diabetes insipidus and diabetes mellitus are unrelated, although they can have similar signs and symptoms, like excessive thirst and excessive urination (see Symptoms of Diabetes for more information on symptoms of diabetes mellitus).
 
Diabetes mellitus (DM) is far more common than diabetes insipidus and receives more news coverage. Diabetes mellitus has two forms, referred to as type 1 diabetes (formerly called juvenile diabetes, or insulin-dependent diabetes mellitus, or IDDM) and type 2 diabetes (formerly called adult-onset diabetes, or noninsulin-dependent diabetes mellitus, or NIDDM). Diabetes insipidus is a different form of illness altogether. Diabetes insipidus occurs when the precise system for regulating the kidneys' handling of fluids is disrupted.
 
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Last reviewed by: Arthur Schoenstadt, MD
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