Diabetes Home > Metformin Drug Interactions

Estrogens
Taking metformin with estrogens can make metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your metformin dose, especially when starting or stopping an estrogen.
 
Isoniazid
Taking metformin with isoniazid can make metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your metformin dose, especially when starting or stopping isoniazid.
 
Niacin
Taking metformin with niacin can make metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your metformin dose, especially when starting or stopping niacin.
 
Oral Contraceptives
Taking metformin with oral contraceptives (birth control pills) can make metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your metformin dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
Taking metformin with phenothiazines can make metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your metformin dose, especially when starting or stopping a phenothiazine.
 
Phenytoin (Dilantin)
Taking metformin with phenytoin can make metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your metformin dose, especially when starting or stopping phenytoin.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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