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More Detail on Metanx Drug Interactions

The following sections explain in detail the potentially negative reactions that can occur when Metanx is combined with any of the drugs listed above.
Aminosalicylic Acid
Aminosalicylic acid may decrease the amount of Metanx absorbed into the bloodstream, potentially decreasing its effectiveness. Talk to your healthcare provider before taking these medications together.
Taking antibiotics with Metanx may decrease the amount of Metanx absorbed into the body from the gastrointestinal (GI) tract. Specifically, antibiotics may affect the absorption of methylcobalamin, one of the active vitamins found in Metanx. Talk to your healthcare provider about this possible interaction before you take an antibiotic with this product.
Bile Acid Sequestrant Medications
Bile acid sequestrant medications may decrease the absorption of one of the vitamins in Metanx (methylcobalamin), which could make the medication less effective. Talk to your healthcare provider before taking these medications together.
Taking capecitabine with Metanx may increase your risk for capecitabine side effects, such as potentially serious gut inflammation (enterocolitis), diarrhea, and dehydration. This interaction may be more severe in older adults. Talk to your healthcare provider before taking Metanx with capecitabine.
Certain Anti-Seizure Medications
Metanx may decrease blood levels of certain medications used to treat seizures, potentially deceasing their effectiveness. In addition, some anti-seizure medications may lower levels of folate in the blood. Because Metanx contains a form of folate, this could make Metanx less effective. Make sure your healthcare provider knows if you take an anti-seizure medication (also sometimes called an anti-epileptic) before you start taking Metanx. He or she may need to monitor you more closely.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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