Diabetes Home > Jentadueto Drug Interactions

P-glycoprotein Inducers
P-glycoprotein is a normal protein found throughout the body. One of its roles is to "pump" harmful or toxic substances out of the tissues so that they can be excreted through the urine or feces.
 
P-glycoprotein helps to remove Jentadueto from the body. However, medications known as P-glycoprotein inducers increase the activity of these proteins. Thus, combining Jentadueto with one of these drugs may cause the body to remove Jentadueto too quickly, potentially making it less effective.
 
Phenothiazines
Taking Jentadueto with phenothiazines can make Jentadueto less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Jentadueto dose, especially when starting or stopping a phenothiazine.
 
Phenytoin
Taking Jentadueto with phenytoin can make Jentadueto less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Jentadueto dose, especially when starting or stopping a phenytoin.
 
Sulfonylureas
Jentadueto may increase the risk of low blood sugar due to sulfonylurea diabetes medications. Your healthcare provider may need to lower the dosage of your sulfonylurea.
 
Thyroid Medications
Taking Jentadueto with thyroid medications can make Jentadueto less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Jentadueto dose, especially when starting or stopping a thyroid medication.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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