Diabetes Home > Jentadueto Alternatives
Oral Diabetes MedicinesMany different types of oral medications are available to treat type 2 diabetes, including:
- Dipeptidyl peptidase inhibitors
- Alpha glucosidase inhibitors
- Ergot alkaloids
- Sodium-glucose co-transporter 2 inhibitors (SGLT2 inhibitors)
- Bile acid sequestrants
- Other combination medications (Jentadueto is a combination medication).
Dipeptidyl Peptidase Inhibitors
Linagliptin (one of the active ingredients in Jentadueto) is part of a class of diabetes medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones. As a DPP-4 inhibitor, linagliptin slows the breakdown of incretin hormones, increasing the level of these hormones in the body. It is this increase in incretin hormones that is responsible for the beneficial actions of linagliptin, such as increasing insulin production in response to meals and decreasing the amount of glucose (sugar) that the liver produces.
Linagliptin is available by itself under the name Tradjenta. There are also three other medications in this class of drugs: sitagliptin (Januvia®), saxagliptin (Onglyza®), and alogliptin (Nesina®).
In addition to linagliptin, the other component in Jentadueto is metformin. Various other metformin products are available under various names (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®). Metformin is the only biguanide medication currently available. It works by helping the body use its natural insulin more effectively. It also decreases sugar (glucose) production by the liver and decreases sugar absorption from the diet