Diabetes Home > Invokana Side Effects
While a majority of people taking Invokana tolerate the medicine well, side effects are possible. Common ones include thirst, increased urination, and urinary tract infections. In addition, there are some potentially serious reactions that you should report immediately to your healthcare provider, such as fainting, difficulty speaking, and blurred vision.
As with any medicine, Invokana® (canagliflozin) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Invokana. Your healthcare provider can discuss a more complete list with you.)
Invokana has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking Invokana were documented and compared to the side effects that occurred in a similar group of people taking a placebo (a "sugar pill" with no active ingredients). As a result, it is possible to see what side effects occurred, how often they appeared, and how they compared to the group taking the placebo.
In these studies, the most common Invokana side effects included:
- Genital fungal infections in women (mostly yeast infections) -- in up to 11.4 percent of people
- Urinary tract infections (such as a bladder infection) -- up to 5.9 percent
- Increased urination -- up to 5.3 percent
- Genital fungal infections in men (mostly infections of the penis in uncircumcised men) -- up to 4.2 percent
- Low blood sugar (hypoglycemia) -- up to 3.6 percent
- Low blood pressure, dizziness, fainting, or dehydration -- up to 3.6 percent
- Vaginal itching -- up to 3 percent
- Thirst -- up to 2.8 percent
- Constipation -- up to 2.3 percent
- Nausea -- up to 2.3 percent.
Invokana typically causes a small decrease in kidney function (as estimated by blood tests). However, episodes of more severe decreases in kidney function (defined as a drop of 30 percent or more) occurred in up to 4.1 percent of people with normal or slightly impaired kidney function and up to 22.5 percent of people with moderate kidney impairment.
Invokana also has a tendency to lower blood pressure by 3.7 to 5.4 mmHg, on average, and to increase LDL cholesterol ("bad cholesterol") by 4.5 to 8 percent, on average.
Weight loss is another possible side effect of Invokana. In studies, people taking Invokana lost an average of 2.8 to 3.9 kg (about 6 to 9 lbs), depending on the dosage, over a period of 26 weeks, compared to a smaller weight loss of slightly more than 1 lb in people taking a placebo.