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Humulin 50/50 Dosing Guidelines

There is no one "standard" Humulin 50/50 dose that will work for all people or even for the same person in all situations. Instead, dosing for Humulin 50/50 must be individualized for each person. Humulin 50/50 is made up of two different insulins, 50 percent intermediate-acting (NPH insulin) and 50 percent short-acting (regular insulin). Compared to Humulin 70/30, it contains a higher percentage of regular insulin for people who need a little more insulin to cover the rise in blood sugar levels after meals. It is typically taken twice a day before meals, often about 30 minutes before eating.
Your healthcare provider may ask you to measure your blood sugar levels before and after meals, and may also recommend carbohydrate counting. Both of these things can help you and your healthcare provider know how to dose your Humulin 50/50.
In some situations, you and your healthcare provider may prefer "aggressive" insulin dosing, which may help reduce the risk of long-term diabetes complications. However, this dosing method also increases the risk of dangerously low blood sugar levels (hypoglycemia). Some people may need more relaxed insulin dosing, especially if they live alone (making it difficult to adequately respond to low blood sugar levels) or if they are elderly (in which case the long-term consequences are less important).

General Information on Your Humulin 50/50 Dosage

Some considerations for people taking Humulin 50/50 include the following:
  • This diabetes medication comes in injectable form. It is injected just under the skin (subcutaneously), usually about half an hour before meals. Typically, it is taken twice a day. Your healthcare provider will decide exactly how and when you should take Humulin 50/50.
  • This insulin comes in vials. To use the vials, you will need insulin syringes (with needles attached). Each time you inject the insulin, you need to use a new needle.
  • Humulin 50/50 comes as a suspension that settles between doses. You must "re-suspend" the insulin before each injection. Shake or rotate the vials until the insulin is uniformly cloudy.
  • Your healthcare provider should show you exactly how to inject Humulin 50/50. It can be injected into the skin and fat layer of the abdomen (stomach), upper arm, or thigh. Choose one of these three areas, and rotate injection sites within your chosen area.
  • Never mix this insulin with any other insulin in the same syringe.
  • For this diabetes drug to work properly, it must be taken as prescribed. It will not work if you stop taking it. Make sure to monitor your blood sugar levels as your healthcare provider recommends.
  • If you are unsure about anything related to your Humulin 50/50 dosage, please talk with your healthcare provider.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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