Diabetes Home > Humalog Drug Interactions

A number of medications can interact negatively with Humalog. Drug interactions can increase blood sugar levels (which is not healthy but not necessarily dangerous), but may also cause dangerously low blood sugar. Medications that can cause some of the more serious drug interactions with Humalog include beta blockers, fibrate cholesterol medicines, oral diabetes drugs, and salicylates.

Humalog Drug Interactions: An Overview

Humalog® (insulin lispro) can potentially interact with numerous other medicines, too many to list. Many of these potential drug interactions are dangerous, while others are not. Some interactions (which are not discussed in this article) may increase blood sugar levels, which is not healthy, but is usually not dangerous right away. Other Humalog drug interactions can result in dangerously low blood sugar levels (hypoglycemia), which can be quite dangerous. Some of the medicines that may cause dangerously low blood sugar when combined with Humalog include:
  • Alcoholic beverages
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors), such as:
  • Monoamine oxidase inhibitors (MAOIs), such as:
    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
  • Sulfonamide antibiotics ("sulfa drugs"), such as:
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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