Diabetes Home > Glyburide

Glyburide is often used to lower blood sugar levels in people with type 2 diabetes. It works by helping the pancreas make more insulin. The medication comes in tablet form, and is typically taken once or twice a day. A micronized glyburide is also available, with small particles that are better absorbed into the body. Possible side effects include stomach problems, low blood sugar, and allergic skin reactions.

What Is Glyburide?

Glyburide (DiaBeta®, Glynase®, or Micronase®) is a prescription medication that is used to treat type 2 diabetes (also known as non-insulin-dependent diabetes or adult-onset diabetes).
 
(Click Glyburide Uses for more information, including possible off-label uses.)
 

Who Makes It?

Sanofi-aventis manufactures DiaBeta, and Pfizer manufactures Glynase and Micronase. Several manufacturers make generic glyburide.
 

How Does Glyburide Work?

Glyburide is part of a class of diabetes medications known as sulfonylureas. They help the pancreas produce more insulin. Sulfonylureas may also help the cells respond better to insulin. This helps to lower blood sugar and keep it under better control.
 

When and How to Take It

General considerations for when and how to take glyburide include the following:
 
  • The medication comes in tablet form. It should be taken by mouth, usually once or twice a day.
  • When taking glyburide once daily, it should be taken with breakfast (or the first main meal).
  • When taking the medication twice daily, the first dose should be taken with breakfast (or the first main meal).
  • Glyburide should be taken at the same time(s) each day to maintain an even level in your blood.
  • For glyburide to work properly, it must be taken as prescribed. The medication will not work if you stop taking it.
     
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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