Diabetes Home > Glyburide Side Effects

Although most people have no problems when taking glyburide, side effects are possible, such as stomach problems or allergic skin reactions. These side effects are usually minor and easily treated. However, some side effects of glyburide are potentially serious and should be reported to your healthcare provider, including chest pain, shortness of breath, or symptoms of high or low blood sugar.

An Introduction to Glyburide Side Effects

As with any medicine, side effects are possible with glyburide (DiaBeta®, Glynase®, or Micronase®). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with glyburide. Your healthcare provider can discuss a more complete list of glyburide side effects with you.)

Common Side Effects of Glyburide

Glyburide has been studied thoroughly in clinical trials, with many people being evaluated. In these studies, the side effects occurring in a group of people taking the drug are always documented and compared to the side effects that occurred in a similar group of people not taking the medicine. As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
Based on these studies, common glyburide side effects include:
  • Stomach problems, such as nausea, heartburn, and a feeling of fullness in the throat or upper chest -- occurring in up to 1.8 percent of people
  • Allergic skin reactions, including rashes, itching, hives, or sensitivity to the sun -- in up to 1.5 percent.
In rare cases, some side effects can occur when taking glyburide with alcohol, including:
  • Nausea
  • Vomiting
  • Stomach cramps
  • Sweating.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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