Diabetes Home > Glyburide Dosing

The glyburide dosing guidelines your healthcare provider will follow depend on how well your diabetes is controlled, other medical conditions you may have, and other medications you are taking. The recommended starting dose is 2.5 mg to 5 mg, taken daily with meals. Your healthcare provider may increase your glyburide dosing, if necessary (2.5 mg or less per week), to the maximum dosage of 20 mg per day.

Glyburide Dosing: An Introduction

The dosing of glyburide (DiaBeta®, Glynase®, or Micronase®) that your healthcare provider prescribes will vary, depending on a number of factors, including:
  • How well your diabetes is controlled
  • Other medical conditions you may have
  • Other medications you are currently taking.
As is always the case, do not adjust your glyburide dose unless your healthcare provider specifically instructs you to do so.

Glyburide Dosing for Type 2 Diabetes

Important information to keep in mind when taking glyburide for type 2 diabetes includes the following:
  • The usual glyburide dose when starting the drug is glyburide 2.5 mg to 5 mg daily (1.5 mg to 3 mg daily if using micronized glyburide), taken with breakfast or the first main meal.
  • People with kidney or liver problems or adrenal or pituitary insufficiency should start with a lower dose, typically glyburide 1.25 mg daily (or 0.75 mg if using micronized glyburide).
  • If switching from chlorpropamide (Diabinese®), special care should be taken to avoid low blood sugar (hypoglycemia), since chlorpropamide can stay in the blood long after you stop taking it.
  • When switching from insulin to glyburide, the starting glyburide dosage depends on your previous insulin dose. Ask your healthcare provider about instructions for switching from insulin to glyburide for your specific situation. You may need to test your blood sugar more often when starting or increasing glyburide.
  • Your healthcare provider may increase your glyburide dose, if needed. The dose can be gradually increased up to 20 mg daily (or up to 12 mg daily for micronized glyburide). The dosage should be increased by 2.5 mg or less per week (or up to 1.5 mg per week for micronized glyburide).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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