Diabetes Home > Glipizide

Glipizide is used to lower blood sugar in people with type 2 diabetes. It works by helping the pancreas make more insulin. The medication comes in tablet form, and is typically taken once or twice a day. Your dosage will depend on how well your diabetes is controlled and other medical conditions you may have, among other things. Potential side effects of glipizide include dizziness, diarrhea, and nervousness.

What Is Glipizide?

Glipizide (Glucotrol®) is a prescription medication used to treat type 2 diabetes (also known as non-insulin-dependent diabetes or adult-onset diabetes). Glipizide extended-release tablets (Glucotrol XL®) are also available. These tablets release the medication slowly, providing a more even level of medication in the blood.
(Click Glipizide Uses for more information, including possible off-label uses.)

Who Makes It?

Brand-name glipizide (Glucotrol and Glucotrol XL) is made by Pfizer, Inc. Generic versions are made by several manufacturers.

How Does Glipizide Work?

Glipizide is part of a group of diabetes medications called sulfonylureas. Sulfonylureas help the pancreas make more insulin. They also help the cells respond better to insulin. This helps to lower blood sugar and keep it under better control.

When and How to Take It

General considerations for when and how to take glipizide include the following:
  • The medication comes in tablet form. It should be taken by mouth.
  • Regular glipizide is usually taken once or twice daily. It works best if taken 30 minutes before breakfast. The extended-release form is taken just once a day with breakfast.
  • Swallow the extended-release tablets whole (do not crush, chew, or break them).
  • Glipizide should be taken at the same time(s) each day to maintain an even level in your blood.
  • For the medication to work properly, it must be taken as prescribed. Glipizide will not work if you stop taking it.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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