Diabetes Home > Diabetes Insipidus Treatment

If you have diabetes insipidus, your treatment options will depend on which type of the condition you have. For example, if you have central diabetes insipidus, you may need a synthetic hormone called desmopressin. The treatment for nephrogenic diabetes insipidus often begins with hydrochlorothiazide or indomethacin.

An Introduction to Treating Diabetes Insipidus

Types of diabetes insipidus include:
A specialist should determine which form of diabetes insipidus is present before starting any treatment.

Central Diabetes Insipidus

Central diabetes insipidus is caused by damage to the hypothalamus or pituitary gland. Central diabetes insipidus treatment usually involves a synthetic hormone called desmopressin that can be taken as an injection, a nasal spray, or a pill.
While taking desmopressin to treat central diabetes insipidus, you should drink fluids or water only when you are thirsty and not at other times. This is because the drug prevents water excretion, and water can build up now that your kidneys are making less urine and are less responsive to changes in body fluids.

Nephrogenic Diabetes Insipidus

Treatment for nephrogenic diabetes insipidus often begins with hydrochlorothiazide (also called HCTZ) or indomethacin. HCTZ is sometimes combined with another drug called amiloride. The combination of HCTZ and amiloride is sold under the brand name Moduretic®. Again, with this combination of drugs, you should drink fluids only when you are thirsty and not at other times.
Written by/reviewed by:
Last reviewed by: Arthur Schoenstadt, MD
Last updated/reviewed:
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