Cycloset is a prescription medicine approved for the treatment of diabetes. Specifically, it is used in combination with diet and exercise to help control blood sugar in people with type 2 diabetes. The medication comes in tablet form and is usually taken within two hours after waking in the morning. Some of the common side effects of this drug include dizziness, vomiting, and fatigue.
(Click Cycloset Uses for more information on what the medication is used for, including possible off-label uses.)
Who Makes This Medication?
Cycloset is made by Patheon, Inc. for VeroScience LLC.
How Does Cycloset Work?
Cycloset belongs to a group of medications known as ergot alkaloids. It works as a dopamine receptor agonist, which means that it binds to and stimulates dopamine receptors. Dopamine is a neurotransmitter (a chemical that transmits signals between nerves).
It is not entirely clear how Cycloset works to control blood sugar, but it is thought that stimulating dopamine receptors in the brain at certain times of the day "resets" the biological clock and improves metabolism. It is thought that seasonal changes in the metabolism of wild animals are due to similar mechanisms.
For years, bromocriptine (the active ingredient in Cycloset) has been used to treat Parkinson's disease, acromegaly (a growth disorder), and hyperprolactinemia (a hormone disorder). Only recently has it been approved for treating diabetes.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins; 2008.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed January 24, 2013.
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