Diabetes Home > Bydureon Drug Interactions

A number of drugs may theoretically cause interactions when combined with Bydureon. In theory, Bydureon may decrease the absorption and effectiveness of certain medications. Also, dangerously low blood sugar levels may occur if it is combined with certain insulin products, such as meglitinide or sulfonylureas. It is also advised to not combine Bydureon with Byetta.

An Overview of Interactions With Bydureon

Bydureon™ (extended-release exenatide) may react with other medications, at least theoretically. It may decrease the absorption of other drugs, and some medications may increase the risk of low blood sugar levels in people using Bydureon.
Also, Bydureon and Byetta® contain the same active ingredient; Byetta contains a short-acting version of exenatide, while Bydureon contains a long-acting version. Therefore, they should never be combined.

Bydureon and Drug Absorption

Bydureon is a prescription diabetes medication that partially works by slowing down the movement of food through the stomach. This action can be helpful for controlling blood sugar levels. However, this also could possibly decrease the absorption of other medications, as most drugs are more effectively absorbed from the small intestine, rather than the stomach. In most cases, this is probably not a problem. However, this interaction could be a problem for any drug that is quite sensitive to small changes.
However, such interactions are still largely theoretical in manner, and studies have not shown that Bydureon decreases the absorption of other drugs to any clinically significant degree. As a good example, theoretically, Bydureon could decrease the absorption of warfarin (Coumadin®, Jantoven®, an anticoagulant "blood thinner" medication), perhaps making it less effective. However, studies have not shown this to be the case. In fact, there have even been a few reports that exenatide (the active ingredient in Bydureon) might even increase the action of warfarin.
To minimize any risks, talk with your healthcare provider or pharmacist about possible drug interactions that may apply to you before starting Bydureon. He or she can review your other medications to see if any of them may be particularly sensitive to any small changes. If you happen to be taking such drugs, you may need to be monitored a little more frequently than usual.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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