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Avandaryl is a combination of two diabetes medicines that are used to control blood sugar levels in people with type 2 diabetes. The medication works by helping your body use its natural insulin better and by causing the pancreas to produce more insulin. It comes in a tablet form that is usually taken once a day. As with any medication, there are potential side effects, such as headaches, low blood sugar, and fluid retention.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandaryl, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandaryl.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.

What Is Avandaryl?

Avandaryl® (rosiglitazone and glimepiride) is a prescription medication that is used to treat type 2 diabetes (also known as non-insulin-dependent diabetes or adult-onset diabetes). The drug is a combination of two different diabetes medications: rosiglitazone maleate (Avandia®) and glimepiride (Amaryl®).
(Click Avandaryl Uses for more information, including possible off-label uses.)

Who Makes It?

Avandaryl is manufactured by GlaxoSmithKline.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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